2013 Fiscal Year Final Research Report
Understanding of molecular mechanisms of synaptonemal complex organization by revealing Zip3 protein network
| Project/Area Number |
24770004
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 減数分裂 / 交叉型組換え / シナプトネマ複合体 / Zip3 |
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| Research Abstract |
During meiosis, crossover formation between homologous chromosomes is essential for proper segregation of homologous chromosomes. In this study, mutation analysis of Zip3 and identification of Zip3-interacting proteins were performed to reveal how Zip3 contributes to meiotic crossover formation. I revealed that 9-1-1 clamp which localizes on DNA double-strand break sites promotes the localization of Zip3 on the chromosomes, then C-terminus of Zip3 recruits the recombination factor, Msh4-Msh5 complex, to the chromosomes.
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