2013 Fiscal Year Final Research Report
Structural basis of mitochondrial proteins involved in anti-viral innate immunity
| Project/Area Number |
24770099
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Structural biochemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
KOSHIBA TAKUMI 九州大学, 理学(系)研究科(研究院), 准教授 (70403970)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ミトコンドリア / 抗ウイルス免疫 / MAVS / 分子間相互作用解析 / BRET |
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| Research Abstract |
Mitochondria-mediated antiviral innate immunity in mammals depends on the activation of RIG-I signaling pathway, and a mitochondrial membrane protein, MAVS plays an important role in the pathway. In the presence study, we found that the activated MAVS conformation is a highly ordered oligomer state by using BRET experiments. Our results reveal structural features underlying the regulation mechanism of MAVS signaling on the mitochondrial membrane.
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[Journal Article] Transglutaminase-catalyzed protein-protein cross-linking suppresses the activity of the NF-κB-like transcription factor Relish2013
Author(s)
Shibata, T., Sekihara, S., Fujikawa, T., Miyaji, R., Maki, K., Ishihara, T., Koshiba, T., and Kawabata, S.
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Journal Title
Sci. Signal
Volume: 6
Pages: ra61
DOI
Peer Reviewed
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[Journal Article] Fis1 acts as mitochondrial recruitment factor for TBC1D15 that involved in regulation of mitochondrial morphology2013
Author(s)
Onoue, K., Jofuku, A., Ban-Ishihara, R., Ishihara, T., Maeda, M., Koshiba, T., Itoh, T., Fukuda, M., Otera, H., Oka, T., Takano, H., Mizushima, N., Mihara, K., and Ishihara, N.
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Journal Title
J. Cell Sci
Volume: 126
Pages: 176-185
DOI
Peer Reviewed
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[Journal Article] A structural perspective of the MAVS-regulatory mechanism on the mitochondrial outer membrane using bioluminescence resonance energy transfer2013
Author(s)
Sasaki, O., Yoshizumi, T., Kuboyama, M., Ishihara, T., Suzuki, E., Kawabata, S., and Koshiba, T.
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Journal Title
Biochim. Biophys. Acta - Mol. Cell Res.
Volume: 1833
Pages: 1017-1027
DOI
Peer Reviewed
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[Journal Article] Microbe-specific C3b deposition in the horseshoe crab complement system in a C2/factor B-dependent or -independent manner2012
Author(s)
Tagawa, K., Yoshihara, T., Shibata, T., Kitazaki, K., Endo, Y., Fujita, T., Koshiba, T., and Kawabata, S.
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Journal Title
PLoS ONE
Volume: 7
Pages: e36783
DOI
Peer Reviewed
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