2013 Fiscal Year Final Research Report
Dynamic regulation of actin filament formation in the innervated skeletal muscle
| Project/Area Number |
24770118
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Functional biochemistry
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
TAKANO Kazunori 千葉大学, 融合科学研究科(研究院), 助教 (60466860)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | 細胞・組織 / シグナル伝達 / 筋原線維形成 / アクチン重合 / 神経支配 / 筋肥大 |
|---|
| Research Abstract |
Striated muscle plays a fundamental role in maintenance of life depending on breathing, exercise and beating of heart by its contractile activity. However, the molecular mechanism how muscle hypertrophy is regulated during growth or pathological processes remains obscure. In denervated skeletal muscle and heart in vivo, this study showed that the N-WASP-mediated actin polymerization activity might be controlled by different mechanisms from that in intact skeletal muscle. In addition, the activity of N-WASP is indispensable for maintenance of heart function during cardiac hypertrophy by pressure-overload. Taken together, these results imply that the regulation of N-WASP activity may be controlled by unknown mechanisms during cardiac hypertrophy and is involved in the maintenance of physiological heart function.
|
-
[Journal Article] The nebulin SH3 domain is dispensable for normal skeletal muscle structure but is required for effective active load bearing in mouse2013
Author(s)
Yamamoto, D. L., Vitiello, C., Zhang, J., Gokhin, D. S., Castaldi, A., Coulis, G., Piaser, F., Filomena, M. C., Eggenhuizen, P. J., Kunderfranco, P., Camerini, S., Takano, K., Endo, T., Crescenzi, M., Luther, P. K., Lieber, R. L., Chen, J., and Bang, M. L.
-
Journal Title
J. Cell Sci.
Volume: 126
Pages: 5477–5489
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
