2013 Fiscal Year Final Research Report
molecular mechanism underlying intracellular heme transport
| Project/Area Number |
24770121
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
UETA Ryo 東京大学, 医科学研究所, 助教 (10445025)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ヘム / 鉄 / ミトコンドリア / 出芽酵母 |
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| Research Abstract |
Using S. cerevisiae, we performed the screening for mutants that are defective in intracellular heme trafficking, and isolated one mutant carrying mutation in a transcriptional regulator. In this mutant, the expression of many genes that are involved in respiration and metabolic pathways processed in mitochondria, suggesting that this transcriptional regulator controls not only heme trafficking, but also mitochondria-related metabolism.
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