2013 Fiscal Year Final Research Report
Identification and functional analysis of mTOR downstream molecules using phospho-proteomic technology
| Project/Area Number |
24770129
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Functional biochemistry
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | mTOR |
|---|
| Research Abstract |
Rapamycin, mTORC1 inhibitor, has drug efficacy of anti-cancer. However, effectors of mTORC1 kinase are not fully understood. To explore the effecetors of mTORC1, we carried out phosphoproteomics analysis and newly identified 30 effectors from the total 20000 phosphopeptides. Next, we analyzed FOXK1 as a transcription factor activated by mTORC1, and identified mTORC1-FOXK1-CCL2 signaling pathway.
|
