2013 Fiscal Year Final Research Report
Analysis of mitochondrial fission in muscle tissue
| Project/Area Number |
24770133
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Kurume University |
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Principal Investigator |
ISHIHARA Takaya 久留米大学, 分子生命科学研究所, 助教 (70611862)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ミトコンドリア / 細胞・組織 / シグナル伝達 / オルガネラ |
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| Research Abstract |
Mitochondria are dynamic organelles, and their fusion and fission regulate various cellular events. We examined the physiological role of mitochondrial fission in muscle tissue. We found that nucleoid morphology/dynamic are regulated by balanced fusion and fission in the term of this project. In healthy cells, mitochondrial fission often occurred adjacent to nucleoids. In Drp1-deficient cells, nucleoids were highly enlarged by their clustering within hyperfused mitochondria. Thus, mitochondrial dynamics by fission and fusion play a critical role in controlling mitochondrial nucleoid structures, contributing to cristae reformation and the proapoptotic status of mitochondria. Further analysis showed that mitochondrial fission maintains functional mitochondria in muscle tissue.
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[Journal Article] Fis1 acts as mitochondrial recruitment factor for TBC1D15 that involved in regulation of mitochondrial morphology2013
Author(s)
Onoue K, Jofuku A, Ban- Ishihara R, Ishihara T, Maeda M, Koshiba T, Itoh T, Fukuda M, Otera H, Oka T, Takano H, Mizushima N, Mihara K and Ishihara N
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Journal Title
Journal of Cell Science
Volume: 126
Pages: 176-185
DOI
Peer Reviewed
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