2013 Fiscal Year Final Research Report
The inhibition mechanism of protein aggregation by extracellular chaperone
| Project/Area Number |
24770150
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Biophysics
|
|---|
| Research Institution | University of Fukui |
|---|
Principal Investigator |
OZAWA Daisaku 福井大学, テニュアトラック推進本部, 助教 (60554524)
|
|---|
| Research Collaborator |
NAIKI Hironobu 福井大学, 医学部, 教授 (10227704)
HASEGAWA Kazuhiro 福井大学, 医学部, 助教 (60324159)
OOKOSHI Tadakazu 福井大学, 医学部, 助教 (90362037)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | シャペロン / 蛋白質品質管理 / アミロイド |
|---|
| Research Abstract |
To reveal the inhibition mechanism of protein aggregation by extracellular chaperone, we searched for new extracellular chaperone and examined its function. Serum amyloid P component and C-reactive protein are members of the pentraxin family of cyclic pentameric protein. These proteins inhibited various amyloid fibril formations in the presence and absence of calcium. Moreover, serum amyloid P component bound to amyloid fibrils and suppressed the cytotoxicity induced by amyloid fibrils. These results suggest that serum amyloid P component and C reactive protein play an important role as new extracellular chaperones that inhibit protein aggregation in vivo.
|
