2014 Fiscal Year Final Research Report
Analyzing the mechanism of recombination-dependent replication restart in eukaryotes
| Project/Area Number |
24770170
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Molecular biology
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | DNA複製フォーク / レプリソーム / 組換え / リン酸化 |
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| Outline of Final Research Achievements |
A replication fork collapsed by a break in the template DNA can be rescued by a recombination-mediated pathway, allowing the re-establishment of a functional replication fork. However, it is not well understood how the replisome components are regulated during fork collapse and restart. In this study, I found that Psf2, a subunit of GINS (a replisome factor), is phosphorylated by ATR/ATM upon fork arrest, which is involved in the replication restart.
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| Free Research Field |
分子生物学、生化学
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