2013 Fiscal Year Final Research Report
The Analysis of Molecular Basis of Mitotic Centromere
| Project/Area Number |
24770180
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Cell biology
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
TANNO Yuji 東京大学, 分子細胞生物学研究所, 助教 (20583123)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | セントロメア / 染色体分配 |
|---|
| Research Abstract |
Equational segregation of sister chromatids is fundamental for inheritance of accurate genetic information. However, the underlying molecular mechanism ensuring equational segregation is unclear. Chromosomal instability (CIN),characterized by a high incidence of unequal segregation, is a hallmark of cancer cells and it has been suggested that CIN promotes initiation and progression of tumorigenesis. However, the molecular mechanism underlying CIN remains elusive. In this study, we found that the molecular pathway that Aurora B promotes accumulation of SGO1 at centromere. Furthermore, we uncovered that the dysfunction of the molecular network regulating centromeric localization of SGO1 can be a major cause of CIN.
|
