2013 Fiscal Year Final Research Report

Regulatory mechanisms for spatiotemporal dynamics of condensins I and II

Research Project

Project/Area Number	24770194
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Cell biology
Research Institution	Institute of Physical and Chemical Research
Principal Investigator	NISHIDE Kenji 独立行政法人理化学研究所, 平野染色体ダイナミクス研究室, 基礎科学特別研究員 (70585067)
Project Period (FY)	2012-04-01 – 2014-03-31
Keywords	染色体 / コンデンシン / 受精卵
Research Abstract	Most eukaryotes utilize two different condensin complexes (known as condensins I and II) to regulate mitotic chromosome assembly and segregation. Interestingly, however, condensins I and II exhibit different subcellular localization during interphase. In this study, I have addressed the question of how the subcellular localization of the two complexes is established in mammalian fertilized eggs and somatic cells. It was found that nuclear export of condensin I by an exportin is responsible for the localization pattern, which appears to be conserved among proliferative cells in mammals.

(4 results)