2013 Fiscal Year Final Research Report
Elucidation of the regulating mechanism of glycolipid synthesis by intracellular energy sensor AMPK
| Project/Area Number |
24770198
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Kyushu University (2013)
The Institute of Physical and Chemical Research (2012) |
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Principal Investigator |
ISHIBASHI Yohei 九州大学, (連合)農学研究科(研究院), 研究員 (90572868)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | スフィンゴ糖脂質 / グルコシルセラミド / AMPK / 糖ヌクレオチド / エネルギー代謝 / 酵素 / 脂質 |
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| Research Abstract |
The amount of cellular glucosylceramide (GlcCer) needs to be regulated in an appropriate level because the abnormal accumulation of GlcCer causes several diseases such as Gaucher's disease and Parkinson's disease. However, insights into how cells regulate GlcCer level are yet to be clarified. AMP-activated protein kinase (AMPK), which is a crucial cellular energy sensor, regulates glucose and lipid metabolism to maintain ATP level. In this study, we investigated whether AMPK affect GlcCer metabolism, and found that GlcCer synthesis was negatively regulated by AMPK-dependent mechanism. Our findings suggest that reduction of GlcCer by AMPK activation may become a new treatment option for diseases caused by the accumulation of GlcCer.
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