Analysis of coordinated regulation of metabolism and ovarian development in Drosophila

2013 Fiscal Year Final Research Report

• Project/Area Number: 24770203
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Developmental biology
• Research Institution: Kurume University
• Principal Investigator: SANO Hiroko 久留米大学, 分子生命科学研究所, 講師 (90506908)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: ショウジョウバエ / 脂肪組織 / インシュリン / エクジソン / 生殖幹細胞ニッチ

Research Abstract

We have studied the mechanisms as to how the Drosophila adipose tissues regulate ovarian development aiming at clarifying coordinated regulation of metabolism and development. In this study, we found that adipose tissue-derived Insulin (Dilp6) and steroid hormone (20-hydroxyecdysone) regulate the formation of terminal filament, which functions as a part of germline stem cell niche in the ovary.

Research Products

• [Journal Article] Isolation of the bioactive peptides CCHamide-1 and CCHamide-2 from Drosophila and their putative role in appetite regulation as ligands for G protein-coupled receptors (2012)
  • Author(s): Ida, T., Takahashi, T., Tominaga, H., Sato, T., Sano, H., Kume, K., Ozaki, M., Hiraguchi, T., Shiotani, H., Terajima, S., Nakamura, Y., Mori, K., Yoshida, M., Kato, J., Murakami, N., Miyazato, M., Kangawa, K., and Kojima, M.
  • Journal Title: F rontires in Endocrinology Volume: 3 Pages: 177
  • DOI: 10.3389
• [Journal Article] The Drosophila actin regulator ENABLED regulates cell shape and orientation during gonad morphogenesis (2012)
  • Author(s): Sano, H., Renault, A., Kunwar, P.S., Barbosa, V., Clark, B.N., Ishihara, S., Sugimura, K., and Lehmann, R.
  • Journal Title: PLoS One Volume: 7 Pages: e52649
  • DOI: 10.1371
• [Presentation] Analysis of the fat body-derived peptide CCHamide-2 in Drosophila (2013)
  • Author(s): Sano, H., Ishimoto, H., Kamikouchi, A., Nakamura, A., Texada, M., Truman, J., Ida, T., and Kojima, M.
  • Organizer: 第36回日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 20131203-06
• [Presentation] Analysis of the peripheral tissue-derived peptides, CCHamide-1 and -2, and dRYamide-1 and -2 in Drosophila (2013)
  • Author(s): Sano, H., Ida, T., and Kojima, M.
  • Organizer: Insect Hormones (19^<th> Ecdysone) International Workshop
  • Place of Presentation: Minneapolis, USA
  • Year and Date: 20130721-26
• [Remarks]
  • URL: http://www.lsi.kurume-u.ac.jp/molecular_genetics/index.html