2013 Fiscal Year Final Research Report
Roles of fibronectin dynamics in tissue remodeling
| Project/Area Number |
24770215
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | Kumamoto University |
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Principal Investigator |
SATO Yuki 熊本大学, 大学院先導機構, 助教 (90508186)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 細胞外基質 / フィブロネクチン / イメージング / 体節 / 内胚葉 |
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| Research Abstract |
This study was aimed at further understanding the mechanisms of tissue morphogenesis from the perspective of cell behaviors and substrate patterning. Fibronectin (FN) fibrils are characteristically patterned between somites, endoderm, and notochord. We investigated the specific role of patterned FN fibrils in cell behaviors, mechanisms underlying patterned FN deposition, and molecules involved in substrate-cell interaction by time-lapse imaging analysis.
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