2013 Fiscal Year Final Research Report
Robust stability of dorsal-ventral patterning by coordination of Chordin and Noggin
| Project/Area Number |
24770223
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Developmental biology
|
|---|
| Research Institution | Institute of Physical and Chemical Research |
|---|
Principal Investigator |
INOMATA HIDEHIKO 独立行政法人理化学研究所, 発生・再生科学総合研究センター, チームリーダー (60372166)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | スケーリング / 背腹軸 / 数理モデル / アフリカツメガエル / 頑強性 / 再構成 |
|---|
| Research Abstract |
Dorsal-ventral patterning of vertebrates is mainly regulated by two dorsalizing factors, Chordin and Noggin. However, it is not clear why two different proteins, which have the same anti-BMP activity, are needed for D-V axis formation. In the present study, we reveal that Chordin and Noggin show different distribution in the embryo. Having high degradation rate, Chordin proteins form steep gradient, while Noggin proteins, which are very stable, form shallow gradient in vivo. Furthermore, Chordin gradient is properly shaped according to the size of the embryo via Chordin degradation.
|
