Dose Fenton reaction occur by iron reduction in vivo?

2014 Fiscal Year Final Research Report

• Project/Area Number: 24780081
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied microbiology
• Research Institution: Tokyo University of Agriculture
• Principal Investigator: SATOH Junichi 東京農業大学, 応用生物科学部, 助教 (70439884)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: フェントン反応 / 鉄 / 鉄還元酵素 / フラビン

Outline of Final Research Achievements

To elucidate the involvement of ferric reductase reaction in Fenton reaction, we purified ferric reductases and iron storage proteins involved in iron reduction. Additionally, we quantified non-protein bound flavin (free flavin) in cells of Escherichia coli and Synechocystis sp. PCC6803 because free flavins were known to be involved in ferric reductase reaction. The ferric reductase reaction was observed under the concentration of the free flavins. These results suggest that the ferric reductase reaction involving free flavins may occur in vivo.

Free Research Field

応用微生物学、生化学