2013 Fiscal Year Final Research Report
Development of the rational method for the synthesis of bioactive cyclic peroxides
| Project/Area Number |
24780110
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MORI NAOKI 東京大学, 農学生命科学研究科, 助教 (60463882)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | oundoperoxide / セスキテルペン / 抗マラリア活性 |
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| Research Abstract |
Bioactive cyclic peroxides are expected to be candidates for new drugs such as antimalarial and anticancer agents. I aimed to develop the rational method for the synthesis of these peroxides and studied the synthrsis of okundoperoxide.
I developed the stereoselective introduction method of peroxide unit by employing the Diels-Alder reaction between silyl dienyl ether and singlet oxygen. First asymmetric total synthesis of okundoperoxide has also been accomplished by using this method.
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