Comprehensive pharmacology of biogenic amine receptors controlling insect feeding behavior for development of new pesticides

2015 Fiscal Year Final Research Report

• Project/Area Number: 24780113
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Bioproduction chemistry/Bioorganic chemistry
• Research Institution: Kumamoto University
• Principal Investigator: Ohta Hiroto 熊本大学, 自然科学研究科, 助教 (60450334)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 昆虫 / 摂食行動 / 生体アミン / 受容体 / 農薬 / カイコ / GPCR / 制御剤

Outline of Final Research Achievements

For development of new insect feeding behavior-regulators, we performed cloning and identification of silkworm biogenic amine receptors and screening of ligands that can regulate the feeding behavior. As the result of cloning, fourteen genes for the amine receptors were isolated. Among them, nine receptors were characterized functionally. Ligand screening revealed that the dopamine receptor BmDopR2 antagonists effectively regulated silkworm feeding behavior.

Free Research Field

農薬科学