2013 Fiscal Year Final Research Report
Identification of target molecule on novel functional peptides in the central nervous system
| Project/Area Number |
24780127
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Utsunomiya University (2013)
Kyoto University (2012) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 低分子ペプチド / 気分障害 / うつ / 不安 / マウス |
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| Research Abstract |
We found that a dipeptide, Tyr-Leu (YL), exhibited antidepressant-like activity by two behavioral tests. In the structure-activity relationship, Leu-Tyr (LY), a retro sequence of YL, have no effect on the antidepressant-like activity, suggesting that YL sequence is important for the activity. In addition, C-terminal elongation of YL tolerated for the antidepressant-like activity.
In the pull-down assay using information of the structure-activity relationship, we found an one-transmenbrane receptor belong to TGF-beta super family as a candidate of target receptor of YL. It has reported that signal pathway via the receptor related to neurogenesis and antidepressants promoted the hippocampal neurogenesis. In the present study, we found preliminarily that YL induced hippocampal neurogenesis. These results supported our hypothesis that YL exhibited antidepressant-like activity via the receptor.
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