Development of new genomedefender foods for the prevention of cancer and lifestyle-related diseases

2014 Fiscal Year Final Research Report

• Project/Area Number: 24780136
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Food science
• Research Institution: Hachinohe National College of Technology
• Principal Investigator: YAMAMOTO Ayumi 八戸工業高等専門学校, その他部局等, 助教 (60523800)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 機能性食品 / ゲノムディフェンダー / 抗変異原 / 抗酸化活性

Outline of Final Research Achievements

We investigated the genome defense activity of extract from blackcurrant using the yeast loss of heterozygosity (LOH) system and the human genotoxicity assays including DNA damage, chromosomal aberration and gene mutation. In the yeast mutation assay, induction of mutations by several mutagens, namely, H2O2, MMS and UV was significantly suppressed by the combined treatment of the two types blackcurrant extracts which were extracted from mature and premature fruits. In the human genotoxicity assays, additionally, DNA damage and chromosomal aberration induced by H2O2-treatment significantly decreased in the each blackcurrant extract treated condition, which were raw and cooked blackcurrant extract. These results suggest that blackcurrant extract treatment can reduce the genomic instability induced by several mutagens. Our findings clearly support the genome defense potential of blackcurrant as a useful food supplement.

Free Research Field

細胞生物学