2013 Fiscal Year Final Research Report

Proposal of safety levels of iron intake from the gene expression analysis of the liver and blood of rats fed the iron excess or deficient diet

Research Project

Project/Area Number	24780139
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Food science
Research Institution	Kanagawa Academy of Science and Technology
Principal Investigator	KAMEI Asuka 公益財団法人神奈川科学技術アカデミー, 「健康・アンチエイジング」プロジェクト, 研究員 (40514112)
Project Period (FY)	2012-04-01 – 2014-03-31
Keywords	DNAマイクロアレイ / 鉄欠乏 / 貧血のない鉄欠乏 / 鉄過剰 / 肝臓 / 血液
Research Abstract	Iron is an essential mineral for the body and its deficient is the problem in the world. In Japan, about 10% of women suffer from iron-deficient anemia, and 20-40% from non-anemic iron deficiency. Iron is also the risk factor of oxidative stress when accumulated in the organs excessively. In this study, by the global analysis of gene expression, a variety of metabolic processes tended to change in the liver of non-anemic iron deficient rats. Also, it was revealed that gene expression patterns in the liver and the blood cells, were changed in rats fed iron-excess diet.