Functional analysis of nucleoporin TMEM48 in the genome dynamics

2014 Fiscal Year Final Research Report

• Project/Area Number: 24780270
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied animal science
• Research Institution: Okayama University
• Principal Investigator: AKIYAMA Kouyou 岡山大学, 学内共同利用施設等, 助教 (20515142)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 疾患モデル動物 / 生殖生物学 / 遺伝学

Outline of Final Research Achievements

The function of the nucleoporin during gametogenesis remains unknown, although the nucleoporin has an important role in various biological natures, such as the nucleo-cytoplasmic transport and nuclear morphology assembly, in vitro. In this study, it is proposed to elucidate the role of the nucleoporin during gametogenesis. As a results, the examinations indicated that the induced-DNA damages are repaired in MEFs without TMEM48 and the SOMOlyation systems may be functional in the sks mice.

Free Research Field

実験動物