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2013 Fiscal Year Final Research Report

Regulation of species--dependent calcium oscillations during fertilization in mammals

Research Project

  • PDF
Project/Area Number 24780272
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Applied animal science
Research InstitutionAzabu University

Principal Investigator

ITO JUNYA  麻布大学, 獣医学部, 准教授 (30454143)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords受精
Research Abstract

We succeeded in molecular cloning of horse PLCz. We also showed that horse PLCz has higher activity compared to those in other mammalian species studied to date. As for the regulation of IP3R in pig oocytes, inhibition of polo-like kinase 1(Plk1) dramatically decreased the expression level of IP3R, suggests that Plk1 is involved in the regulation of IP3R expression at least in pig oocytes.

  • Research Products

    (9 results)

All 2013 2012 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (3 results) Book (1 results)

  • [Journal Article] Molecular characteristics of horse phospholipase C zeta (PLCz)2013

    • Author(s)
      Kana Sato, Takuya Wakai, Yasunari Seita, Akiko Takizawa, Rafael A. Fissore, Junya Ito, Naomi Kashiwazaki
    • Journal Title

      Animal Science Journal

      Volume: 84 Pages: 359-368

    • DOI

      10.1111/asj.12044

    • Peer Reviewed
  • [Journal Article] Generation of live offspring from vitrified mouse oocytes of C57BL/6J strain2013

    • Author(s)
      Natsuki Kohaya, Katsuyoshi Fujiwara, Junya Ito, Naomi Kashiwazaki
    • Journal Title

      PLoS ONE

      Volume: 8 Pages: e58063

    • DOI

      10.1371/journal.pone.0058063

    • Peer Reviewed
  • [Journal Article] Vitrification procedure decreases inositol 1,4,5-trisphophate receptor expression, resulting in low fertility of pig oocytes2013

    • Author(s)
      Masahiko Hirose, Maki Kamoshita, Katsuyoshi Fujiwara, Tsubasa Kato, Ayaka Nakamura, Richard Wojcikiewicz, Jan B. Parys, Junya Ito, Naomi Kashiwazaki
    • Journal Title

      Animal Science Journal

      Volume: 84 Pages: 693-701

    • DOI

      10.1111/asj.12061

    • Peer Reviewed
  • [Journal Article] Molecular mechanism of fertilization in the pig2012

    • Author(s)
      Junya Ito, Naomi Kashiwazaki
    • Journal Title

      Animal Science Journal

      Volume: 83 Pages: 669-682

    • DOI

      10.1111/j.1740-0929.2012.01044.x

    • Peer Reviewed
  • [Journal Article] The effect of M-phase stage-dependent kinase inhibitors on inositol 1,4,5-trisphosphate receptor 1 (IP_3R1) expression and localization in pig oocytes

    • Author(s)
      Anucha Sathanawongs, Katsuyoshi Fujiwara, Tsubasa Kato, Masahiko Hirose, Maki Kamoshita, Richard J.H. Wojcikiewicz, Jan B. Parys, Junya Ito, Naomi Kashiwazaki
    • Journal Title

      Animal Science Journal

      Volume: (in press)

    • Peer Reviewed
  • [Presentation] Characteristics of transgenic rats expressing horse PLCz2013

    • Author(s)
      Junya Ito, Yuki Yamashita, Koji Furukawa, Ayaka Nakamura, Kana Sato, Akiko Takizawa, Hoi Chang Lee, Rafael A. Fissore, Naomi Kashiwazaki
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      アメリカ合衆国
    • Year and Date
      20130700
  • [Presentation] Activation of round spermatid-injected oocytes using phospholipase C zeta in pigs2013

    • Author(s)
      Junya Ito, Emi Yuhara, Ayaka Nakamura, Naomi Kashiwazaki
    • Organizer
      Annual Meeting of International Embryo Tranafer Society
    • Place of Presentation
      ドイツ
    • Year and Date
      20130100
  • [Presentation] Improvement of in vitro and in vivo development of vitrified mammalian oocytes and embryos2012

    • Author(s)
      Junya Ito
    • Organizer
      Annual Meeting of Asia Reproductive Biology Society
    • Place of Presentation
      フィリピン
    • Year and Date
      20121000
  • [Book] The Ca^<2+> signal at fertilization in mammals: PLC, sterility, and species-specific differences in activity. Sperm Cell Research in the 21st Century: Historical Discoveries to New Horizons Chapter 10:2012

    • Author(s)
      Junya Ito and Rafael A. Fissore
    • Total Pages
      180-183

URL: 

Published: 2015-06-25  

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