2013 Fiscal Year Final Research Report
Why do MRL mice produce oocytes in their testes - analysis of producing mechanism and fuctional evaluation of testicular oocyte
| Project/Area Number |
24780278
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Hokkaido University |
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Principal Investigator |
OTSUKA Saori 北海道大学, (連合)獣医学研究科, 助教 (10566152)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 発生・分化 / MRL/MpJマウス / 性分化 / 精巣内卵細胞 |
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| Research Abstract |
There is only one autosomal causative gene for production of testicular oocytes in MRL/MpJ mice. In addition, the related gene for this phenotype seems to locate on chromosome 15. The fetal testicular oocytes show the similar methylation patterns of histone and DNA to ovarian oocytes at the same age. Furthermore, right testes of fetal and postnatal MRL/MpJ mice contain significantly higher number of testicular oocytes than left testes.
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