2013 Fiscal Year Final Research Report
Spatiotemporal mechanisms regulating seasonal rhythms in affective states
| Project/Area Number |
24780286
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Kyushu University |
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Principal Investigator |
YASUO SHINOBU 九州大学, (連合)農学研究科(研究院), 准教授 (30574719)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 光周性 / 情動 / セロトニン / 脳 / マウス |
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| Research Abstract |
Animals living in temperate zones alter their stress- and mood-related physiology to seasonal changes in the environment by using the photoperiod as a primary cue. In human, seasonal affective disorder (SAD) is marked by depression during specific seasons, generally winter. This study clarified that the brain serotonergic system is regulated by photoperiod through the network between brain and peripheral metabolisms, using a mouse strain that exhibits high depression-like behavior under short photoperiod. Additionally, this study identified the antidepressant-like effect of bright light treatment, which was potentiated by a functional amino acid that has modulatory roles of the circadian clock. These data suggest that photoperiod-induced changes in mood can be regulated by light and nutrition.
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[Journal Article] Photoperiodic responses of depression-like behavior, the brain serotonergic system, and peripheral metabolism in laboratory mice2014
Author(s)
Otsuka T, Kawai M, Togo Y, Goda R, Kawase T, Matsuo H, Iwamoto A, Nagasawa M, Furuse M, Yasuo S
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Journal Title
Psychoneuroendocrinology
Volume: 40
Pages: 37-47
DOI
Peer Reviewed
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