Molecular pathology of iron dysregulation during progression of liver cirrhosis

2013 Fiscal Year Final Research Report

• Project/Area Number: 24780288
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: Osaka Prefecture University
• Principal Investigator: IZAWA Takeshi 大阪府立大学, 生命環境科学研究科(系), 助教 (20580369)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 肝硬変 / 鉄代謝障害 / 鉄調節因子

Research Abstract

We investigated the molecular mechanism of iron overload, a risk factor of liver cirrhosis. As in humans, iron overload progressed during the progression of cirrhosis in rats, which was accompanied by suppression of hepcidin transcription (a central regulator of iron homeostasis) and inactivation of IL6-STAT3 pathway (an inducer of hepcidin transcription). These data suggests that the impaired hepcidin induction can be involved in the iron overload during progression of cirrhosis.

Research Products

• [Journal Article] M1- and M2-macrophage polarization in rat liver cirrhosis induced by thioacetamide (TAA), focusing on Iba1 and galectin-3 (2014)
  • Author(s): Wijesundera KK, Izawa T(共同筆頭著者), Tennakoon AH, Murakami H, Golbar HM, Katou-Ichikawa C, Tanaka M, Kuwamura M, Yamate J
  • Journal Title: Exp Mol Pathol Volume: 96(3) Pages: 382-392
  • Peer Reviewed
• [Journal Article] M1- and M2-macrophage polarization in thioacetamide (TAA)-induced rat liver lesions; a possible analysis for hepato-pathology (2014)
  • Author(s): Wijesundera KK, Izawa T, Murakami H, Tennakoon AH, Golbar HM, Kato-Ichikawa C, Tanaka M, Kuwamura M, Yamate J
  • Journal Title: Histol Histopathol Volume: 29(4) Pages: 497-511
  • Peer Reviewed
• [Journal Article] Inflammatory regulation of iron metabolism during thioacetamide-induced acute liver injury in rats (2013)
  • Author(s): Izawa T, Murakami H, Wijesundera KK, Golbar HM, Kuwamura M, Yamate J
  • Journal Title: Exp Toxicol Pathol Volume: 66(2-3) Pages: 155-162
  • Peer Reviewed
• [Journal Article] Characterization of glial fibrillary acidic protein (GFAP)-expressing hepatic stellate cells and myofibroblasts in thioacetamide (TAA)-induced rat liver injury (2013)
  • Author(s): Tennakoon AH, Izawa T, Wijesundera KK, Golbar HM, Tanaka M, Ichikawa C, Kuwamura M, Yamate J
  • Journal Title: Exp Toxicol Pathol Volume: 65(7-8) Pages: 1159-1171
  • Peer Reviewed
• [Journal Article] Expressions of Iba1 and galectin-3 (Gal-3) in thioacetamide (TAA)-induced acute rat liver lesions (2013)
  • Author(s): Wijesundera KK, Juniantito V, Golbar HM, Fujisawa K, Tanaka M, Ichikawa C, Izawa T, Kuwamura M, Yamate J
  • Journal Title: Exp Toxicol Pathol Volume: 65(6) Pages: 799-808
  • Peer Reviewed
• [Journal Article] Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis (2013)
  • Author(s): Uehara T, Ainslie GR, Kutanzi K, Pogribny IP, Muskhelishvili L, Izawa T, Yamate J, Kosyk O, Shymonyak S, Bradford BU, Boorman GA, Bataller R, Rusyn I
  • Journal Title: Toxicol Sci Volume: 132(1) Pages: 53-63
  • Peer Reviewed
• [Presentation] 食餌性鉄過剰・鉄欠乏によるラット肝臓の病理学的変化 (2014)
  • Author(s): 井澤武史,宮城伶奈,堀内貴至,桑村充,山手丈至
  • Organizer: 第30回日本毒性病理学会学術集会
  • Place of Presentation: 徳島
  • Year and Date: 20140130-31
• [Presentation] 肝硬変の進展に関わる新規miRNAの病理学的役割の検討 (2013)
  • Author(s): 堀内貴至,井澤武史,Wijesundera K,桑村充,山手丈至
  • Organizer: 第30回日本毒性病理学会学術集会
  • Place of Presentation: 徳島
  • Year and Date: 20130920-23
• [Presentation] イヌの肝・胆道系疾患の傾向とその病理学的特徴 (2013)
  • Author(s): 堀内貴至,井澤武史,井澤敬子,桑村充,山手丈至
  • Organizer: 第155回日本獣医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 20130328-31
• [Presentation] ラット肝硬変モデルにおける鉄代謝障害の分子メカニズムの解明 (2012)
  • Author(s): 村上宙,井澤武史,Wijesundera K,Golbar HM,Tennakoon A,桑村充,山手丈至
  • Organizer: 第154回日本獣医学会学術集会
  • Place of Presentation: 盛岡
  • Year and Date: 20120914-16
• [Remarks]
  • URL: http://www.vet.osakafu-u.ac.jp/path/path.html