2013 Fiscal Year Final Research Report
Basic study on the role of matricryptins in cardiac remodeling
| Project/Area Number |
24780289
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 循環器 / 心臓リモデリング / 細胞外マトリックス / Matricryptins / Endostatin / Canstatin / 心線維芽細胞 / 心筋細胞 |
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| Research Abstract |
The fundamental study was performed to elucidate the role of matricryptins, bioactive fragments of extracellular matrix, in the heart. Endostatin, one of the matricryptins, increased the proliferation and migration of rat cardiac fibroblasts, and inhibited bradykinin-induced left atrial contraction in mice. In addition, another matricryptin canstatin increased the expression of cyclooxygenase-2 and cell migration through the secretion of matrix metalloproteinase-2 and -9 in rat cardiac fibroblasts, and inhibited isoproterenol-induced cell death in differentiated H9c2 cardiomyoblasts.
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