2013 Fiscal Year Final Research Report

Identification of autoantibodies in dogs with autoimmune endcrinopathies

Research Project

Project/Area Number	24780307
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Clinical veterinary science
Research Institution	Gifu University
Principal Investigator	NISHII Naohito 岐阜大学, 応用生物科学部, 准教授 (20508478)
Project Period (FY)	2012-04-01 – 2014-03-31
Keywords	自己抗体 / 犬 / 副腎皮質機能低下症 / 甲状腺機能低下症
Research Abstract	We have developed the method for detecting autoantibodies against proteins isolated from canine adrenocortical gland and other tissues. Autoantibodies against the adrenal proteins were detected in 11 to 33% of dogs with hypoadrenocorticism. In these dogs, hypoadrenocorticism might be related to the autoimmune response. Anti-ovary protein autoantibodies were also detected, which indicated an autoimmune reaction against multiple endocrine tissues. In addition, multiple autoantibodies were found in dogs with hypoadrenocorticism or hypthyroidism. These proteins need to be identified. Results in this study may contribute to diagnosis or research of canine hypoadrenocorticism and hypothyroidism.