Mechanism of bovine abomasal displacement - based on smooth muscle reseach

2015 Fiscal Year Final Research Report

• Project/Area Number: 24780316
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Clinical veterinary science
• Research Institution: Nippon Veterinary and Life Science University
• Principal Investigator: Tajima Tsuyoshi 日本獣医生命科学大学, 獣医学部, 助教 (60508878)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 中鎖脂肪酸 / TLR4 / 消化管常在型マクロファージ / iNOS / NO / 平滑筋収縮機能障害 / エイコサペンタエン酸

Outline of Final Research Achievements

The aim of the study is to reveal mechanism of abomasal dismotility that lies behind bovine abomasal displacement (AD) based on smooth muscle contraction. In organ culture model of bovine abomasum, we found medium chain fatty acids activateed Toll-like receptor 4 (TLR4) and enhanced inducible NO synthase (iNOS) and NO production in gastric resident macrophages. Diffused NO affected abomasal smooth muscle dysmotility. Lauric acid was increased in displaced abomasal tissue but not in blood. On the other hand, blood eicosapentaenoic acid (EPA) was decreased, meaning TLR4 signaling by medium fatty acids was enhanced.These results highlight the pathophysiological role of medium fatty acids in AD and also show that the monitoring of blood EPA may contribute for the early diagnosis of AD.

Free Research Field

獣医臨床薬理学