2013 Fiscal Year Final Research Report
Innovative Synthetic Studies toward Aminal Alkaloids based on Control of Cascade Oxidative Skeletal Rearrangement
| Project/Area Number |
24790003
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
UEDA HIROFUMI 東北大学, 薬学研究科(研究院), 助教 (50581279)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 有機化学 / 有機合成化学 / 天然物合成化学 / アルカロイド / 酸化反応 / カスケード反応 |
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| Research Abstract |
We focused our attention on syntheses of aminal alkaloids having a densely fused polycyclic skeleton utilizing the cascade oxidative skeletal rearrangement and other original methods found in synthetic studies. As a result of our extensive studies, we successful achieved the total syntheses of haplophytine, isoschizogamine, leuconoxine, gliocladin C, and T988s with novel oxidation reactions developed by our group.
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