2013 Fiscal Year Final Research Report
Development of novel reactions using iron catalyst and silicon reagents
| Project/Area Number |
24790016
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 鉄触媒 / シリル系試薬 / 環開裂反応 |
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| Research Abstract |
Since iron is inexpensive and safe, the development of the novel organic reactions using iron catalyst is valuable. We newly established two type iron-catalyzed reactions. (1) The iron-catalyzed functionalizations of tetrahydrofurans and oxanorbornadiene derivatives accompanied with the ring-opening of carbon-oxygen bonds can provide the pharmaceutically useful skeltones. (2) Although the siloxy and methoxy groups possess the low abilities as leaving groups, we discovered that the siloxy and methoxy groups could be easily eliminated by the use of iron catalyst to give the various products. This methodology is valuable to enable the reduction of cost and synthetic steps.
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