2013 Fiscal Year Final Research Report
Development of peptide ligation using chemical properties of boron
| Project/Area Number |
24790020
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 有機合成化学 / 触媒反応 / 触媒 / ペプチド / アミド / ホウ素 / ボロン酸 |
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| Research Abstract |
The amide functionality is one of the most fundamental chemical building blocks. It constitutes the backbone of the biological and synthetic materials such as proteins, polymers and pharmaceuticals. In this research, we aimed at the development of catalytic and direct amide formation reaction of carboxylic acid with amine using organoboron. As a result, a series of sulfanyl organoboronic acids has been synthesized. The substituent effect of sulfanyl functional group was demonstrated by amidation of simple carboxylic acid and simple amine.
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[Journal Article]2014
Author(s)
Watanabe, Y.; Shimada, N.; Anada, M.; Hashimoto, S.
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Journal Title
Tetrahedron : Asymmetry
Volume: 25
Pages: 63-73
DOI
Peer Reviewed
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[Journal Article]2012
Author(s)
Shimada, N.; Stewart, C.; Bow, W. F.; Jolit, A.; Wong, K.; Zhou, Z.; Tius, M. A.
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Journal Title
Angew. Chem. Int. Ed.
Volume: 51
Pages: 5727-5729
DOI
Peer Reviewed
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