2014 Fiscal Year Final Research Report
Development of novel cascade reactions of alkyne derivatives for the efficient synthetic procedures of heterocycles
| Project/Area Number |
24790024
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
SAITO AKIO 東京農工大学, 工学(系)研究科(研究院), 准教授 (10339103)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | アルキン / 複素環 / 金触媒 / ヨウ素試薬 |
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| Outline of Final Research Achievements |
We have developed the efficient synthetic methods of heterocyclic compounds by means of cascade reactions and multi-component reactions based on each of the following reactions: 1) syntheses of polycyclic isochromane and benzofuran via Au-catalyzed carboalkoxylation reactions, 2) syntheses of oxazoles and imidazoles by metal-free [2+2+1]annulation reactions, and 3) syntheses of fluorinated oxazoles through hypervalent iodine-mediated cycloisomerization-fluorination reaction.
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| Free Research Field |
有機合成化学
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