2014 Fiscal Year Final Research Report
Research and development of a novel palladium catalyst
| Project/Area Number |
24790031
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | パラジウム / 球状形成活性炭 / 不均一系触媒 / 官能基選択的 / 接触還元 / プロセス化学 |
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| Outline of Final Research Achievements |
We have developed a highly chemoselective hydrogenation method using a novel and heterogeneous palladium catalyst supported on spherical carbon (Pd/SC) under mild reaction conditions, which is applicable for the hydrogenation of alkyne, alkene, azide, nitro, and aliphatic O-tert-butyldimethylsilyl (TBS) ether functionalities leaving the benzyl ester, benzyl ether, nitrile, aromatic ketone, N-benzyloxycarbonyl (Cbz) protective group, and aromatic O-TBS ether functionalities intact. The present method could accomplish the requirement for both laboratory and industrial applications.
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| Free Research Field |
有機化学
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