Development and application of efficient reactions using unstable species

2015 Fiscal Year Final Research Report

• Project/Area Number: 24790032
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Chemical pharmacy
• Research Institution: Hyogo University of Health Sciences
• Principal Investigator: YOSHIOKA Eito 兵庫医療大学, 薬学部, 助教 (80435685)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 複素環合成 / ベンザイン / ラジカル / π結合挿入反応 / [2+2]型反応 / 多成分連結反応 / カスケード反応

Outline of Final Research Achievements

I studied the following reactions using unstable chemical species such as aryne and radical for developing rapid and/or efficient reactions. In general, it was difficult to control the reaction using these species. But I succeeded new one-pot synthesis of dihydrobenzofuran, benzofuran, and 4H-chromene via the insertion reaction of aryne into the C=O pai-bond of formamides. I also developed catalytic radical cascade reactions in aqueous media using the photocatalyst under visible light irradiation. I reported the results of experiments to prove the utility of the dye-supported polycrystalline titanium dioxide in the hydrogenation of aromatic ketones.

Free Research Field

薬学・化学系薬学