2013 Fiscal Year Final Research Report
Developments of environmentally-benign C-C bond formation reactions via C-O bond cleavage
| Project/Area Number |
24790035
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
WANG Chao 独立行政法人理化学研究所, 環境資源科学研究センター, 特別研究員 (90610436)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 環境調和型反応 / クロスカップリング反応 / 炭素―酸素結合切断 / 有機亜鉛試薬 / 有機アルミニウム試薬 / 反応機構理論解析 / 遷移金属フリー反応 |
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| Research Abstract |
(1) The first cross-coupling between organozincate and aryl ether via cleaving etheric C-O bond was achieved. Some of the results were publised in Chem. Eur. J. and was highlighted in SYNFACTAS as "SYNFACTS of the month". (2) The first transition-metal-ctalyst-free cross-coupling between organozinc reagent and oeganic halide was accomplished. Some of the results were publised in Eur. J. Org. Chem. (3) Mechanistic investigations for several important organic reactions were successfully performed by using computational and theoretical methods. Some of the results were publised in Eur. J. Org. Chem., J. Am. Chem. Soc., etc.
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