2014 Fiscal Year Final Research Report
In situ suspended state NMR investigation into a solid dipersion after dispersed into water
Project/Area Number |
24790041
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Physical pharmacy
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Research Institution | Chiba University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Keywords | suspended state NMR / 固体分散体 / 溶解性 / Eudragit / HRMAS / 固体NMR / 相溶性 / 分子間相互作用 |
Outline of Final Research Achievements |
Solid dispersion, which is composed of drug and polymer, has been used to improve the solubility and absorption of poorly water soluble drugs. In this study, the structure and state of solid dispersion after dispersed into water was evaluated at molecular level. Here, the advanced techniques of nuclear magnetic resonance (NMR) directly detected the state of both drug and polymer, and the intermolecular interaction between them. Furthermore, the dissolution mechanism of solid dispersion was clarified by simultaneous determination of the dissolution rate of drug and polymer after dispersed the solid dispersion into water.
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Free Research Field |
分子製剤学
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