2013 Fiscal Year Final Research Report
Development of novel DDS drugs targeting for glioma tumor vasculogenic mimicry
| Project/Area Number |
24790050
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical pharmacy
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 脳腫瘍 / 擬似血管 / 抗体 / ファージ表面提示法 / DDS / 免疫療法 |
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| Research Abstract |
In this study, we had an attempt to develop a novel drug delivery therapy for glioma.In particular, we had tried to create specific antibody for tumor vasculogenic mimicry(VM), which was reported that it was associated with tumor growth and metastasis.
In vitro, I had constructed glioma VM model cell forming de novo vascular networks. Next, the glioma VM antibody library had been developed by the immunization of glioma VM cell proteins. In addition, the number of high affinity antibodies for VM had been enhanced by affinity panning for VM proteins.
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