2013 Fiscal Year Final Research Report
Development of novel platform for injectable in vivo drug delivery system
| Project/Area Number |
24790052
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical pharmacy
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
ASAI Daisuke 聖マリアンナ医科大学, 医学部, 助教 (10423485)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ドラッグデリバリー / ハイドロゲル / 生分解材料 / ポリペプチド / 薬物デポ / インジェクタブルポリマー / ペプチド / 温度応答性高分子 |
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| Research Abstract |
The final goal of our study is: (1) to discover the seeds of next-generation biomedicine for infectious disease and cancer therapy; (2) to develop biocompatible materials for supporting surgical treatment. In this study, we focused elastin protein which expresses universally as an elastic fiber of vertebrates. We carried out the rational design and recombinant synthesis of thermally responsive peptide polymer-based hydrogels composed of an elastin-like polypeptide that rapidly forms a reversibly cross-linked hydrogel by the formation of intermolecular mild oxidative cross-links. We showed the utility of the hydrogels for the sustained release of medicines and the ability as to be an injectable and biodegradable material. These materials will find useful application in drug delivery and tissue engineering.
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Research Products
(16 results)
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[Journal Article] Protein polymer hydrogels by in situ, rapid and reversible self-gelation2012
Author(s)
Asai, D., Xu, D., Liu, W., Garcia Quiroz, F., Callahan, D.J., Zalutsky, M.R., Craig, S.L., and Chilkoti, A
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Journal Title
Biomaterials
Volume: 33
Pages: 5451-5458
DOI
Peer Reviewed
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[Journal Article] Brachytherapy using injectable seeds that are self-assembled from genetically encoded polypeptide in situ2012
Author(s)
Liu, W., McDaniel, J.R., Li, X., Asai, D., Garcia Quiroz, F., Schaal, J., Park, J.S., Zalutsky, M.R., and Chilkoti, A
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Journal Title
Cancer Res
Volume: 72
Pages: 5956-5965
DOI
Peer Reviewed
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[Presentation] Preparation of cancer-signal-responsive gene carrier via native chemical ligation2013
Author(s)
Funamoto, D., Mori, T., Asai, D., Niidome, T., and Katayama, Y
Organizer
4th Asian Biomaterials Congress
Place of Presentation
Hong Kong, China
Year and Date
20130626-31
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[Presentation] Thermally-responsive Elastin-like polypeptide engineered to locally deliver radionuclide payload leads to complete regression of solid tumor2012
Author(s)
Liu, W., McDaniel, J.R., Li, X., Asai, D., Zalutsky, M.R., and Chilkoti, A
Organizer
9th World Biomaterials Congress
Place of Presentation
Chengdu, China
Year and Date
20120601-05
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[Presentation] Preclinical studies on tumor retention, antitumor efficacy and toxicity of thermally responsive polypeptide-based radionuclide intratumoral depot in nude mice2012
Author(s)
Liu, W., McDaniel, J.R., Li, X., Asai, D., Zalutsky, M.R., and Chilkoti, A
Organizer
American Association for Cancer Research Annual Meeting 2012
Place of Presentation
Chicago, IL, USA
Year and Date
20120401-04
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