2013 Fiscal Year Final Research Report

Development of lipid bilayer membrane vesicles constructed by fat-soluble vitamin and application for cancer treatment

Research Project

Project/Area Number	24790060
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Physical pharmacy
Research Institution	National Institute of Health Sciences
Principal Investigator	UN Keita 国立医薬品食品衛生研究所, 薬品部, 研究員 (80624535)
Project Period (FY)	2012-04-01 – 2014-03-31
Keywords	リポソーム / コレカルシフェロール
Research Abstract	In this study, we determined that cholecalciferol-derivative containing liposomes are interacted with caveolin-1 on the cell surface, and taken up into the cells via caveolae-mediated endocytosis. Moreover, we showed that cholecalciferol-derivative containing liposomes possess the cytotoxic activities, and increase the pharmaceutical activities of the other medicines such as anti-cancer agents. Since the cholecalciferol-derivatives used in this study have already been investigated the metabolic and eliminating process in the body, these components have high biocompatibility. Therefore, these results obtained from this study contribute to pharmaceutical development for the construction of effective and safe medication.

(2 results)