2013 Fiscal Year Final Research Report
Study on a regulation system of intracellular cholesterol transport by ceramide kinase
| Project/Area Number |
24790066
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | セラミドキナーゼ / セラミド-1-リン酸 / 細胞内コレステロール輸送 |
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| Research Abstract |
Ceramide kinase produces the bioactive lipid ceramide-1-phosphate and appears as a key enzyme for regulating cell growth and arachidonic acid metabolism. In this study, to elucidate a novel physiological function, we focused on the transport of intracellular cholesterol. We showed that ceramide kinase is a negative regulator of the cholesterol transport from late endosomes to endoplasmic reticulum.
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[Journal Article] Effects of Hsp90 inhibitors, geldanamycin and its analog, on ceramide metabolism and cytotoxicity in PC12 cells2012
Author(s)
Toyomura K, Saito T, Emori S, Matsumoto I, Kato E, Kaneko S, Okuma Y, Nakamura H, Murayama T
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Journal Title
Journal of Toxicological Sciences
Volume: 37
Pages: 1049-1057
DOI
Peer Reviewed
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