2013 Fiscal Year Final Research Report
The regulation of G2 DNA damage checkpoint recovery by Src family kinases
| Project/Area Number |
24790067
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | DNA損傷 / 細胞周期 |
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| Research Abstract |
We showed that the regulation of DNA damage checkpoint recovery by Src family kinases involves the regulation of ATR-dependent Rad17 phosphorylation as a key event, and that the underlying molecular mechanism involves the inhibition of the interaction between Rad17 and Rad9. Src family kinases are also involved in ATM-Chk2 checkpoint pathway and replication checkpoint recovery. We also showed the regulation of Kap1 and Cdc5L by tyrosine phosphorylation and the regulation of checkpoint recovery by imatinib. These data shed light on the role of Src family kinases in the termination of DNA damage checkpoint signaling.
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[Journal Article] Phosphorylation of KRAB-associated protein 1 (KAP1) at Tyr-449, Tyr-458, and Tyr-517 by nuclear tyrosine kinases inhibits the association of KAP1 and heterochromatin protein 1α(HP1α) with heterochromatin2013
Author(s)
Sho Kubota, Yasunori Fukumoto, Kazumasa Aoyama, Kenichi Ishibashi, Ryuzaburo Yuki, Takao Morinaga, Takuya Honda, Noritaka Yamaguchi, Takahisa Kuga, Takeshi Tomonaga, and Naoto Yamaguchi
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Journal Title
J. Biol. Chem
Volume: 288
Pages: 17871-17883
DOI
Peer Reviewed
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[Journal Article] Src family kinases promote silencing of ATR-Chk1 signaling in termination of DNA damage checkpoint
Author(s)
Yasunori Fukumoto, Mariko Morii, Takahito Miura, Sho Kubota, Kenichi Ishibashi, Takuya Honda, Aya Okamoto, Noritaka Yamaguchi, Atsushi Iwama, Yuji Nakayama, and Naoto Yamaguchi
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Journal Title
J. Biol. Chem
Volume: (in press)
DOI
Peer Reviewed
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[Presentation] Src型チロシンキナーゼによるATM依存的DNA損傷チェックポイントからのリカバリー促進2014
Author(s)
福本泰典,九鬼和雅,森井真理子,三浦崇仁,本田拓也,石橋賢一,長谷川仁美,久保田翔,井出雄大,山口憲孝,中山祐治,山口直人
Organizer
日本薬学会第134年会
Place of Presentation
熊本
Year and Date
20140327-30
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[Presentation] KAP1のチロシンリン酸化によるHP1αのヘテロクロマチン領域への結合阻害2014
Author(s)
久保田翔,福本泰典,青山和正,石橋賢一,幸龍三郎,盛永敬郎,本田拓也,森井真理子,山口憲孝,久家貴寿,朝長毅,山口直人
Organizer
日本薬学会第134年会
Place of Presentation
熊本
Year and Date
20140327-30
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[Presentation] KAP1のチロシンリン酸化によるクロマチン構造変化と転写制御2013
Author(s)
久保田翔,福本泰典,青山和正,石橋賢一,幸龍三郎,盛永敬郎,本田拓也,山口憲孝,久家貴寿,朝長毅,山口直人
Organizer
第86回日本生化学会大会
Place of Presentation
大阪
Year and Date
20130911-13
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