2013 Fiscal Year Final Research Report
Analysis of bone selective androgen and estrogen receptor modulators.
| Project/Area Number |
24790071
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
HIRATA MICHIKO 東京農工大学, 工学(系)研究科(研究院), 講師 (40544060)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 骨粗鬆症 / エストロゲン / アンドロゲン / 受容体作働薬 |
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| Research Abstract |
Bone remodeling is regulated by bone resorption and formation. Estrogen deficiency induced by menopause results in marked bone loss in women. The elderly men exhibit marked bone loss due to androgen deficiency. We developed the new osteoporosis drugs with minimal undesired effects on reproductive tissues. Carboranes restored bone loss in orchidectomized mice without androgenic action in the sex organs. These result indicated that Carboranes are novel selective androgen receptor modulators (SARM) that may offer a new therapy option for osteoporosis.
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[Journal Article] Synthesis of vitamin D(3) derivatives with nitrogen-linked substituents at A-ring C-2 and evaluation of their vitamin D receptor-mediated transcriptional activity2012
Author(s)
Abe J, Nagai Y, Higashikuni R, Iida K, Hirokawa T, Nagai H, Kominato K, Tsuchida T, Hirata M, Inada M, Miyaura C, Nagasawa K
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Journal Title
Org Biomol Chem
Volume: 10(38)
Pages: 7826-7839
Peer Reviewed
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