2013 Fiscal Year Final Research Report
Analysis for role of calumin in lipid transport of polarized cells
| Project/Area Number |
24790073
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ERAD |
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| Research Abstract |
Calumin is a novel ER-resident protein. Disruption of calumin gene in mice causes embryonic lethality, suggesting that calumin plays the indispensable physiological role. But, the physiological role of calumin is not clear.
To maintain ER homeostasis, ER is equipped with ERAD functioning as protein quality control system. This study suggests not only the importance of calumin in ERAD but also the significance of ERAD in visceral endoderm cells functioning as the very few secretory cells around the embryonic day when calumin-knockout mice die.
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[Journal Article] TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells2012
Author(s)
Nishi M, Aoyama F, Kisa F, Zhu H, Sun M, Lin P, Ohta H, Van B, Yamamoto S, Kakizawa S, Sakai H, Ma J, Sawaguchi A, Takeshima H
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Journal Title
The J ournal of Biological Chemistry
Volume: 287
Pages: 33523-33532
DOI
