2013 Fiscal Year Final Research Report
Molecular mechanisms of permeability transition revealed using quantitative proteomic analysis
| Project/Area Number |
24790076
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | The University of Tokushima |
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Principal Investigator |
YAMAMOTO Takenori 徳島大学, 疾患プロテオゲノム研究センター, 講師 (80457324)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ミトコンドリア / 透過性遷移 / プロテオミクス |
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| Research Abstract |
Mitochondrial permeability transition triggers subsequent steps of apoptosis. To understand the molecular mechanisms of permeability transition, we here performed the quantitative proteomic analysis to identify the regulatory proteins for permeability transition. As a result, we found some candidate proteins, which were oxidized when a permeability transition inducer was added to isolated mitochondria. We will examine whether the proteins are related to the regulation of permeability transition.
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