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2015 Fiscal Year Final Research Report

Function of sialidase in hippocampal-dependent memory

Research Project

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Project/Area Number 24790080
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biological pharmacy
Research InstitutionUniversity of Shizuoka

Principal Investigator

Minami Akira  静岡県立大学, 薬学部, 講師 (80438192)

Project Period (FY) 2012-04-01 – 2016-03-31
Keywordsシアリダーゼ / イメージング / 蛍光プローブ / 記憶 / 海馬 / シアル酸 / N-グリコリルノイラミン酸 / ラット
Outline of Final Research Achievements

Sialidase removes sialic acid residues from sialoglycoconjugates such as glycoproteins and glycolipids. Since sialic acid plays crucial roles in synaptic plasticity and memory in the hippocampus, regulation of sialyl signaling by sialidase is also necessary for neural functions. In this projects, we found that sialidase is essential for hippocampal-dependent memory.

Free Research Field

神経糖鎖生物学

URL: 

Published: 2017-05-10  

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