2015 Fiscal Year Final Research Report
Function of sialidase in hippocampal-dependent memory
| Project/Area Number |
24790080
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
Minami Akira 静岡県立大学, 薬学部, 講師 (80438192)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | シアリダーゼ / イメージング / 蛍光プローブ / 記憶 / 海馬 / シアル酸 / N-グリコリルノイラミン酸 / ラット |
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| Outline of Final Research Achievements |
Sialidase removes sialic acid residues from sialoglycoconjugates such as glycoproteins and glycolipids. Since sialic acid plays crucial roles in synaptic plasticity and memory in the hippocampus, regulation of sialyl signaling by sialidase is also necessary for neural functions. In this projects, we found that sialidase is essential for hippocampal-dependent memory.
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| Free Research Field |
神経糖鎖生物学
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