2013 Fiscal Year Final Research Report
Mechanism of regulation of gene expression by polyamines at the level of translation depending on the interaction of polyamines with RNA
| Project/Area Number |
24790084
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Chiba Institute of Science |
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Principal Investigator |
TERUI YUSUKE 千葉科学大学, 薬学部, 講師 (60433687)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ポリアミン / 細胞増殖 / 細胞生存率 / バイオフィルム / 大腸菌 / プトレスシン / スペルミジン / 翻訳 |
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| Research Abstract |
Polyamines are essential for normal cell growth and cell viability. Polyamines exist mostly as polyamine-RNA complexes in cells. A group of genes whose expression is enhanced by polyamines at the level of translation be referred to as a "polyamine modulon".
Since biofilm formation is also involved in cell viability, we looked for proteins involved in biofilm formation and cell viability whose synthesis is stimulated by polyamines at the level of translation in Escherichia coli. It was found that the synthesis of UvrY, CpxR and RRF was increased by polyamines at the level of translation. The results indicate that polyamines are necessary for both biofilm formation and cell viability.
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Research Products
(10 results)
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[Journal Article] Role of polyamines at the G1/S boundary and G2/M phase of the cell cycle2013
Author(s)
YAMASHITA Tomoko, NISHIMURA Kazuhiro, SAIKI Ryotaro, OKUDAIRA Hiroyuki, TOME Mayuko, HIGASHI Kyohei, NAKAMURA Mizuho, TERUI Yusuke, FUJIWARA Kunio, KASHIWAGI Keiko, IGARASHI Kazuei
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Journal Title
International J ournal of Biochemistry and Cell Biology
Volume: Vol 45
Pages: 1042-1050
Peer Reviewed
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[Journal Article] Enhanced biofilm formation and/or cell viability by polyamines through stimulation of response regulators UvrY and CpxR in the two-component signal transducing systems, and ribosome recycling factor2012
Author(s)
SAKAMOTO Akihiko, TERUI Yusuke, YAMAMOTO Taku, KASAHARA Takuma, NAKAMURA Mizuho, TOMITORI Hideyuki, YAMAMOTO Kaneyoshi, MICHAEL Anthony J., IGARASHI Kazuei, KASHIWAGI Keiko
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Journal Title
International J ournal of Biochemistry and Cell Biology
Volume: vol 44
Pages: 1877-1886
Peer Reviewed
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[Presentation] Role of polyamines at the G1/S boundary and G2/M phase of the cell cycle2013
Author(s)
KASHIWAGI Keiko, Yamashita Tomoko, NISHIMURA Kazuhiro, SAIKI Ryotaro, OKUDAIRA Hiroyuki, TOME Mayuko, HIGAHI Kyohei, NAKAMURA Mizuho, TERUI Yusuke, FUJIWARA Kunio, IGARASHI Kazuei
Place of Presentation
Waterville Valley、USA
Year and Date
2013-06-16
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