Effects of endoplasmic reticulum stress in embryonic stage on neurodevelopmental disorders

2014 Fiscal Year Final Research Report

• Project/Area Number: 24790085
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: Chiba Institute of Science
• Principal Investigator: KAWADA Koichi 千葉科学大学, 薬学部, 講師 (30581631)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 小胞体ストレス / 自閉症 / 神経成熟 / 神経分化 / HRD1

Outline of Final Research Achievements

Autism spectrum disorder (ASD) is a congenital type of the central nervous system such as abnormal synaptogenesis. Relevance to endoplasmic reticulum (ER) stress and ASD is not reported. In this study, I have investigated the effects of ER stress on neuronal differentiation and maturation.
In the brain of ASD model mice, I found the condition of high ER stress and the enhancement of neuronal differentiation. In the culture cells, ER stress led to the enhancement of neuronal differentiation and the inhibition of neurite outgrowth. These events were normalized by the inhibition of ubiquitin ligase HRD1 expression.
The pathogenesis of ASD may be associated with increased HRD1 via high ER stress in the neuronal developmental process.

Free Research Field

神経薬理学