2014 Fiscal Year Final Research Report
Regulation of immune responses by IL-23 p19, IL-27 EBI3 or their new heterodimer
| Project/Area Number |
24790091
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | IL-27 / EBI3 / 腸炎 / IL-23R |
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| Outline of Final Research Achievements |
In the present study, we found that the common subunit, EBI3, between the IL-6/IL-12 family cytokines IL-27 and IL-35 plays a novel role as an intracellular molecule in IL-27/IL-35-independent manner. Namely, EBI3 was presumably demonstrated to associate with the scaffold protein p62/SQSTM1, which plays a critical role in the degradation of ubiqutinated protein by autophagy, and therefore inhibit the degradation of ubiqutinated IL-23 receptor, possibly resulting in induction of colitis by augmentation of IL-23 signaling.
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| Free Research Field |
免疫学
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