2013 Fiscal Year Final Research Report
Study on artificial nucleic acids design based on the glycosidic bond angle control
| Project/Area Number |
24790110
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
KODAMA Tetsuya 名古屋大学, 創薬科学研究科, 准教授 (00432443)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 核酸 / 有機化学 / 核酸医薬 / 薬学 / 創薬科学 / 人工核酸 |
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| Research Abstract |
Several artificial nucleic acids bearing 7-deazapurine-analog were synthesized and those torsion angles about glycosidic bond were estimated. We found that bridged nucleic acids have a similar glycosidic bond angle to RNA to stabilize the double stranded oligonucleotides. Moreover, nucleic acids bearing tetrahydropyran or cyclohehene as a sugar moiety were synthesized. These artificial nucleic acids showed a high resistance to 5'-3' exonuclease, and one of nucleic acids bearing a tetrahydropyran sugar present a high stabilization property of duplex oligonucleotides.
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