2013 Fiscal Year Final Research Report
Development of novel anticancer drugs targeting for controlling the function and expression of oxidative stress-induced protein
| Project/Area Number |
24790114
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
ENDO Satoshi 岐阜薬科大学, 薬学部, 助教 (60433207)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | aldo-keto reductases / 抗癌剤 / 抗癌剤耐性抑制薬 |
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| Research Abstract |
Aldo-keto reductases (AKR) which are induced by oxidative stress via Keap1/Nrf2 pathway are suggested to involve in proliferation and survival of cancer cells. Then, we searched novel AKR inhibitors for anticancer therapeutic development and have succeeded the development of the most potent and high selective AKR inhibitors and construction of AKR stably expressing cancer cells. These results would facilitate the development of novel anticancer drugs targeting for AKR.
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[Journal Article] Synthesis and structure-activity relationship of 2-phenylimino chromene derivatives as inhibitors for aldo-keto reductase (AKR) 1B10、Bioorg2014
Author(s)
Satoshi Endo, Dawei Hu, Miho Suyama, Toshiyuki Matsunaga, Kenji Sugimoto, Yuji Matsuya, Ossama El-Kabbani, Kazuo Kuwata, Akira Hara, Yukio Kitade, Naoki Toyooka
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Journal Title
Med. Chem
Volume: vol21
Pages: 6378-6384
DOI
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[Journal Article] Rabbit 3-hydroxyhexobarbital dehydrogenase is a NADPH-preferring reductase with broad substrate specificity for ketosteroids, prostaglandin D2, and other endogenous and xenobiotic carbonyl compounds、Biochem2014
Author(s)
Satoshi Endo, Toshiyuki Matsunaga, Atsuko Matsumoto, Yuki Arai, Satoshi Ohno, Ossama El-Kabbani, Kazuo Tajima, Yukio Kitade, Yasuo Bunai, Shigeru Yamano, and Akira
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Journal Title
Pharmacol
Volume: Vol.86、No.9
Pages: 1366-1375
DOI
Peer Reviewed
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[Journal Article] Characterization of a rabbit morphine 6-dehydrogenase and its two isoforms which function as NAD+-dependent 3α(17β)- hydroxysteroid dehydrogenases2012
Author(s)
Satoshi Endo, Toshiyuki Matsunaga, Airi Fujimoto, Sho Kumada, Yuki Arai, Yoko Miura, Hiroshige Mikamo, Ossama El-Kabbani, Shigeru Yamano, Munekazu Iinuma, Akira Hara
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Journal Title
Arch. Biochem. Biophys
Volume: Vol.529、No.2
Pages: 131-139
DOI
Peer Reviewed
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